The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea
stagnalis is the established model for the ligand binding domains of the ligand-gated ion …

The growing interest in nicotinic receptors, because of their wide expression in neuronal and
non‐neuronal tissues and their involvement in several important CNS pathologies, has …

We delineated acetylcholine (ACh)-dependent conformational changes in a prototype of the
nicotinic receptor ligand binding domain by molecular dynamics simulation and changes in …

The nicotinic acetylcholine receptor is a well characterized ligandgated ion channel, yet a
proper description of the mechanisms involved in gating, opening, closing, ligand binding …

We have entered the age of structural neurobiology. After decades of envying our
colleagues who work on soluble proteins, we have our first structural insights into the …

The gating motion of the human nicotinic acetylcholine receptor (nAChR) α7 was
investigated with normal mode analysis (NMA) of two homology models. The first model …

The main immunogenic region (MIR) is a conformation-dependent region at the extracellular
apex of α1 subunits of muscle nicotinic acetylcholine receptor (AChR) that is the target of …

The acetylcholine-binding protein (AChBP) is homologous to the ligand-binding domain of
the nicotinic acetylcholine receptor (nAChR) and other members of the Cys-loop family of …