The conversion of proteins from their soluble states into well-organized fibrillar aggregates is
associated with a wide range of pathological conditions, including neurodegenerative …

A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

As substantial constituents of the multiple myeloma (MM) microenvironment, pro-
inflammatory macrophages have emerged as key promoters of disease progression, bone …

Objective: This review focuses on the current knowledge on the implication and significance
of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate. Data Sources …

We describe a kindred with slowly progressive gastrointestinal symptoms and autonomic
neuropathy caused by autosomal dominant, hereditary systemic amyloidosis. The amyloid …

Purpose: We aimed to maximize the performance of detecting genetic alterations in lung
cancer using high-throughput sequencing for patient-derived xenografts (PDXs) …

Evolutionary pressure for protein function leads to unavoidable sampling of conformational
states that are at risk of misfolding and aggregation. The resulting tension between …

β 2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-
term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic …

Several protein misfolding diseases are associated with the conversion of native proteins
into ordered protein aggregates known as amyloid. Studies of amyloid assemblies have …

The discovery of methods suitable for the conversion in vitro of native proteins into amyloid
fibrils has shed light on the molecular basis of amyloidosis and has provided fundamental …