The win ratio was introduced in 2012 as a new method for examining composite endpoints
and has since been widely adopted in cardiovascular (CV) trials. Improving upon …

Background Smokers have a substantially increased risk of postoperative complications.
Preoperative smoking intervention may be effective in decreasing this incidence, and …

Background The efficacy of ivermectin in preventing hospitalization or extended observation
in an emergency setting among outpatients with acutely symptomatic coronavirus disease …

Background The efficacy of a single dose of pegylated interferon lambda in preventing
clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

Background The effect on cardiovascular outcomes of withholding angiotensin-converting
enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac …

The conventional reporting of composite endpoints in clinical trials has an inherent limitation
in that it emphasizes each patient's first event, which is often the outcome of lesser clinical …

Background Statins reduce the incidence of cardiovascular events in persons with type 2
diabetes mellitus. However, the benefit of statins in such patients receiving hemodialysis …

Background Research suggests that fetal exposure to magnesium sulfate before preterm
birth might reduce the risk of cerebral palsy. Methods In this multicenter, placebo-controlled …

Background—We sought to determine the concordance between the accumulating evidence
about the impact of tight versus less tight glycemic control in patients with type 2 diabetes …