D Wang, Y Yang, Y Lei, NT Tzvetkov, X Liu… - Pharmacological …, 2019 - ASPET
Foam cell formation and further accumulation in the subendothelial space of the vascular wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …
SJCM Frambach, R de Haas, JAM Smeitink… - Pharmacological …, 2020 - ASPET
Atherosclerosis is a leading cause of cardiovascular disease worldwide, and hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …
R Menacho-Melgar, JS Decker, JN Hennigan… - Journal of Controlled …, 2019 - Elsevier
The use of biologics (peptide and protein based drugs) has increased significantly over the past few decades. However, their development has been limited by their short half-life …
Cardiovascular disease (CVD) remains a leading cause of mortality and morbidity worldwide. Numerous therapies are currently under investigation to improve pathological …
W Annema, A von Eckardstein - Translational Research, 2016 - Elsevier
Low plasma levels of high-density lipoprotein (HDL) cholesterol are associated with increased risks of coronary heart disease. HDL mediates cholesterol efflux from …
Alzheimer's disease (AD) represents a progressive amyloidogenic disorder whose advancement is widely recognized to be connected to amyloid-β peptides and Tau …
DR Coelho, PH Carneiro, L Mendes-Monteiro… - Journal of …, 2021 - Am Soc Microbiol
Dengue is a mosquito-borne infectious disease that is highly endemic in tropical and subtropical countries. Symptomatic patients can rapidly progress to severe conditions of …
Apolipoprotein AI (apoA-I) mediates reverse cholesterol transport (RCT) out of cells. In addition to its important role in the RTC, apoA-I also possesses anti-inflammatory and …
K Kornmueller, I Vidakovic, R Prassl - Molecules, 2019 - mdpi.com
Lipoproteins are endogenous nanoparticles which are the major transporter of fats and cholesterol in the human body. They play a key role in the regulatory mechanisms of …