Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry
Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …
heterocyclic compound with a wide range of pharmacological prospective such as …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
Quinoline: Synthesis to application
This review aims to provide a comprehensive report on the quinoline ring with respect to its
synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal …
synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal …
[HTML][HTML] Molecular modelling studies for 4-oxo-1, 4-dihydroquinoline-3-carboxamide derivatives as anticancer agents
The ligand library reporting anticancer activities was taken from literature containing forty-
two 4-oxo-1, 4-dihydroquinoline-3-carboxamides derivatives and was thoroughly …
two 4-oxo-1, 4-dihydroquinoline-3-carboxamides derivatives and was thoroughly …
BiCl 3-catalyzed green synthesis of 4-hydroxy-2-quinolone analogues under microwave irradiation
Traditional chemical synthesis, which involves the use of dangerous protocols, hazardous
solvents, and toxic products and catalysts, is considered environmentally inappropriate and …
solvents, and toxic products and catalysts, is considered environmentally inappropriate and …
Novel quinoline-4-carboxamide derivatives potentiates apoptosis by targeting PDK1 to overcome chemo-resistance in colorectal cancer: Theoretical and experimental …
V Shalini, AN Priyadarshini, VK DC, D Gowda… - Heliyon, 2024 - cell.com
A series of novel N, 2-diphenyl-6-(aryl/heteroaryl) quinoline-4-carboxamide derivatives were
designed and synthesized using the Suzuki coupling reaction and evaluated them for their …
designed and synthesized using the Suzuki coupling reaction and evaluated them for their …
Regioselective 1, 2-hydroboration of N-heteroarenes using a potassium-based catalyst
T Liu, J He, Y Zhang - Organic Chemistry Frontiers, 2019 - pubs.rsc.org
Herein, we present a regioselective hydroboration of N-heteroarenes with pinacolborane
(HBpin) in the presence of commercially available potassium-based catalysts, leading to 1, 2 …
(HBpin) in the presence of commercially available potassium-based catalysts, leading to 1, 2 …
Chemistry and Applications of 4-Hydroxyquinolin-2-one and Quinoline-2, 4-dionebased Compounds
K Proisl, S Kafka, J Kosmrlj - Current Organic Chemistry, 2017 - ingentaconnect.com
Background: 4-Hydroxyquinolin-2-ones and quinoline-2, 4-diones, a subset of the quinolone
scaffold, have attracted attention due to their biological properties. These structures are …
scaffold, have attracted attention due to their biological properties. These structures are …
Design, synthesis, and evaluation of new 2-oxoquinoline arylaminothiazole derivatives as potential anticancer agents
Y Fang, Z Wu, M Xiao, L Wei, K Li, Y Tang, J Ye… - Bioorganic …, 2021 - Elsevier
A series of novel 2-oxoquinoline derivatives containing arylaminothiazole were designed
and synthesized as potential antitumor agents. The synthesized compounds were evaluated …
and synthesized as potential antitumor agents. The synthesized compounds were evaluated …