The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

All known life forms trace back to a last universal common ancestor (LUCA) that witnessed
the onset of Darwinian evolution. One can ask questions about LUCA in various ways, the …

Structural biology studies performed inside cells can capture molecular machines in action
within their native context. In this work, we developed an integrative in-cell structural …

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …

Staphylococcus aureus is a preeminent bacterial pathogen capable of colonizing diverse
ecological niches within its human host. We describe here the pangenome of S. aureus …

The principles of mRNA decoding are conserved among all extant life forms. We present an
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …

Protein synthesis by the ribosome is highly dependent on the ionic conditions in the cellular
environment, but the roles of ribosome solvation have remained poorly understood …

Modified nucleotides in tRNA are critical components of the translation apparatus, but their
importance in the process of translational regulation had until recently been greatly …

For a more complete understanding of molecular mechanisms, it is important to study
macromolecules and their assemblies in the broader context of the cell. This context can be …

Functional tRNA molecules always contain a wide variety of post-transcriptionally modified
nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with …