The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell
death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

Aberrations in centrosome numbers have long been implicated in aneuploidy and
tumorigenesis, but their origins are unknown. Here we have examined how overexpression …

Microtubules are highly dynamic cellular polymers made of αβ-tubulin and associated
proteins. They play a key role during mitosis, participating in the exact organization and …

The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …

Here we investigate the role of the control of apoptosis in normal cell division. We show that
interference with the expression or function of the apoptosis inhibitor survivin causes …

Chronic exposure of many human hepatoma cell lines to a low dose (LD) of doxorubicin
induced a senescence-like phenotype (SLP) accompanied by enlargement of cells and …

Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed,
both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive …

Centrosomes play critical roles in processes that ensure proper segregation of
chromosomes and maintain the genetic stability of human cells. They contribute to mitotic …

Genomic instability is intrinsically linked to significant alterations in apoptosis control.
Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic …