Antidepressant-and anxiolytic-like activities and acute toxicity evaluation of the Psilocybe cubensis mushroom in experimental models in mice

A Hernandez-Leon, RI Escamilla-Orozco… - Journal of …, 2024 - Elsevier
Ethnopharmacology relevance Central nervous system (CNS) diseases can be diverse and
usually present with comorbidity, as in the case of depression and anxiety. Despite …

Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice

CW Thomas, C Blanco-Duque, BJ Bréant… - Translational …, 2022 - nature.com
Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N, N-dimethyltryptamine),
profoundly alter the quality of consciousness through mechanisms which are incompletely …

Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice

X Liu, H Zhu, H Gao, X Tian, B Tan, R Su - Biochemical and Biophysical …, 2022 - Elsevier
HT 2A receptor is a member of the family A G-protein-coupled receptor. It is involved in many
psychiatric disorders, such as depression, addiction and Parkinson's disease. 5-HT 2A R …

The novel non-hallucinogenic compound DM506 (3-methyl-1, 2, 3, 4, 5, 6-hexahydroazepino [4, 5-b] indole) induces sedative-and anxiolytic-like activity in mice by a …

HR Arias, D Rudin, DJ Hines, A Contreras… - European Journal of …, 2024 - Elsevier
The anxiolytic and sedative-like effects of 3-methyl-1, 2, 3, 4, 5, 6-hexahydroazepino [4, 5-b]
indole (DM506), a non-hallucinogenic compound derived from ibogamine, were studied in …

Cortical Correlates of Psychedelic-Induced Shaking Behavior Revealed by Voltage Imaging

T Buchborn, T Lyons, C Song, A Feilding… - International Journal of …, 2023 - mdpi.com
(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a
reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to …

Microstructure abnormalities of the diffusion quantities in children with attention-deficit/hyperactivity disorder: an AFQ and TBSS study

R Hu, F Tan, W Chen, Y Wu, Y Jiang, W Du… - Frontiers in …, 2023 - frontiersin.org
Objective To explore the specific alterations of white matter microstructure in children with
attention-deficit/hyperactivity disorder (ADHD) by automated fiber quantification (AFQ) and …

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: translational implications

O Shahar, A Botvinnik, N Esh-Zuntz… - International Journal of …, 2022 - mdpi.com
There is increasing interest in the therapeutic potential of psilocybin. In rodents, the
serotonin precursor, 5-hydroxytryptophan (5-HTP) and psilocybin induce a characteristic 5 …

Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep

JJ Fraigne, PH Luppi, CE Mahoney, R De Luca… - Sleep, 2023 - academic.oup.com
The discovery of REM sleep is attributed to the landmark observations of Eugene Aserinsky
and Nathaniel Kleitman. In 1953, they identified periods of „active sleep‟ that are marked by …

Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice

CW Thomas, C Blanco-Duque, B Bréant, GM Goodwin… - bioRxiv, 2021 - biorxiv.org
Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N, N-dimethyltryptamine),
profoundly alter the quality of consciousness through mechanisms which are incompletely …

Psychedelic Use and Psychological Flexibility: The Role of Decentering, Mystical Experiences, Ego-Dissolution, and Insight

WM Campo - 2022 - academicworks.cuny.edu
The purpose of this study was to investigate potential associations between psychological
flexibility (PF) and characteristics of the psychedelic experience: self-perceived meaningful …