The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …

The Nef protein of the human immunodeficiency virus is as important for disease
progression as it is perplexing in its plethora of target molecules and functions. In this article …

1. ABSTRACT Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired
immune deficiency syndrome (AIDS), a disease characterized by CD4+ T lymphocyte …

Nef is an HIV-1 virulence factor that promotes viral pathogenicity by altering host cell
signaling pathways. Nef binds several members of the Src kinase family, and these …

The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important determinant of
AIDS pathogenesis. We have previously reported that HIV-1 Nef is responsible for the …

SH2 domains are long known prominent players in the field of phosphotyrosine recognition
within signaling protein networks. However, over the years they have been joined by an …

A main feature of HIV infection is the expression of several proinflammatory cytokines.
Proinflammatory cytokines expressed as soluble factors or membrane-bound molecules …

Caveolae and lipid rafts are two distinct populations of free cholesterol, sphingolipid
(FC/SPH)-rich cell surface microdomains. They differ in stability, shape, and the presence or …

The Nef protein produced by the viruses HIV-1 and SIV drives efficient viral replication
partially by inducing constitutive activation of host cell tyrosine kinases, including members …

Interleukin-2 tyrosine kinase (Itk), is a T-cell specific tyrosine kinase of the Tec family. We
have examined a novel intermolecular interaction between the SH3 and SH2 domains of Itk …