The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that
orchestrate cell migration, hematopoiesis and cell homing, and retention in the bone …

Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

Over the last decade, the rapid emergence of multidrug-resistant pathogens has become a
global concern, which has prompted the search for alternative antibacterial agents for use in …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Antimicrobial peptides (AMPs) are multi-functional peptides whose fundamental biological
role in vivo has been proposed to be the elimination of pathogenic microorganisms …

Antimicrobial peptides (AMPs) are evolutionarily conserved molecules involved in the
defense mechanisms of a wide range of organisms. Produced in bacteria, insects, plants …

Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular
dystrophies. The causative gene remains controversial and the mechanism of …

Defensins are an effector component of the innate immune system with broad antimicrobial
activity. Humans express two types of defensins, α-and β-defensins, which have antiviral …

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Defensins have been long recognized as natural antimicrobial peptides, but they also
possess diverse and versatile immune functions. Defensins can both induce inflammation …