Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

Tumor cell migration toward and intravasation into capillaries is an early and key event in
cancer metastasis, yet not all cancer cells are imbued with the same capability to do so. This …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin
cytoskeleton. They were originally thought to primarily affect cell migration and invasion; …

The hepatitis B virus-like particle (HBV VLP) is an attractive protein nanoparticle platform
due to the availability of 240 modification sites for engineering purposes. Although direct …

We previously reported that Ganoderma lucidum extract (GLE) demonstrate significant anti-
cancer activity against triple negative inflammatory breast cancer models. Herein, we aimed …

Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …

Cell adhesion and migration are regulated through the concerted action of cytoskeletal
dynamics and adhesion proteins, the activity of which is governed by RhoGTPases. Specific …