Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets
after transplantation. In type 1 diabetes, beta cells are destroyed by immunological …

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-
producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is …

Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of
insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of
pancreatic β-cells. One of the earliest aspects of this process is the development of …

Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1
diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent …

Recent advances in immunotherapeutics have not yet changed the routine management of
autoimmune type 1 diabetes. There is an opportunity to repurpose therapeutics used to treat …

The tumor suppressor p53 regulates apoptosis, cell cycle, and oncogenesis. To explore the
roles of p53 in autoimmunity, we studied type 1 diabetes and innate immune responses …

Type 1 diabetes results from autoimmune destruction of pancreatic β-cells by CD8+ T cells.
The requirement for CD8+ T cells implicates perforin and granzymes as effectors of tissue …

Suppressor of cytokine signalling‐1 (SOCS1), as the name implies, is a protein that
functions as a negative regulator of cytokine signalling. Initially characterized for its ability to …

Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading
to insulin deficiency. Although infiltrating immune cells are traditionally considered to …