Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal
development and in cancer progression. EMT is induced by various signaling pathways …

Precise coordination of cell fate decisions is a hallmark of multicellular organisms.
Especially in tissues with non-stereotypic anatomies, dynamic communication between …

A major question in systems biology is how to identify the core gene regulatory circuit that
governs the decision-making of a biological process. Here, we develop a computational …

Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly
differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 …

One of the key questions in systems biology is to understand the roles of gene regulatory
circuits in determining cellular states and their functions. In previous studies, some …

In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased
by the overexpression of a few genes, resulting in regaining pluripotency, the potential for …

One of the major challenges in biology is to understand how gene interactions collaborate to
determine overall functions of biological systems. Here, we present a new computational …

Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation.
The Waddington landscape posits that gene circuits in a cell form a potential landscape of …

While aerobic glycolysis, or the Warburg effect, has for a long time been considered a
hallmark of tumor metabolism, recent studies have revealed a far more complex picture …