[HTML][HTML] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …
[图书][B] Investigating the Polyketide Metabolite GEX1A: A Splicing Inhibitor with Implications for Niemann-Pick Type C Disease
MC Rhodes - 2021 - search.proquest.com
Polyketide natural products have drawn attention from the synthetic community due to
complex molecular structures and unique biological activities. Polyketides are …
complex molecular structures and unique biological activities. Polyketides are …
[图书][B] Designing Structural and Conformational Analogs from Polyketide Natural Products
CAU Gamboa - 2023 - search.proquest.com
Our laboratory has utilized total synthesis, semi-synthesis, and fermentation of bacterial
species to produce natural product analogs to study the relationship between …
species to produce natural product analogs to study the relationship between …
Alternative pre-mRNA splicing as a source of cancer neoepitopes
A Knudsen - 2023 - archiv.ub.uni-heidelberg.de
Robust identification of neoepitopes is crucial for the efficacy and safety of immunotherapy,
the most promising treatment strategy for several cancer types. Current approaches have …
the most promising treatment strategy for several cancer types. Current approaches have …
[图书][B] Immune consequences and therapeutic targeting of disrupted mRNA splicing in cancer
EJ De Neef - 2022 - search.proquest.com
Immunotherapies, such as checkpoint blockade, CAR-T cells, and vaccines, have proven to
be a valuable tool to treat various types of cancer. This class of therapy capitalizes on the …
be a valuable tool to treat various types of cancer. This class of therapy capitalizes on the …