Annexin A1 as a regulator of immune response in cancer

TG Araújo, STS Mota, HSV Ferreira, MA Ribeiro… - Cells, 2021 - mdpi.com
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

Annexin 1: the new face of an old molecule

LHK Lim, S Pervaiz - The FASEB Journal, 2007 - Wiley Online Library
The annexin superfamily consists of 13 calcium or calcium and phospholipid binding
proteins with a significant degree of biological and structural homology (40–60%). First …

Programmed cell removal: a new obstacle in the road to developing cancer

MP Chao, R Majeti, IL Weissman - Nature Reviews Cancer, 2012 - nature.com
The development of cancer involves mechanisms by which aberrant cells overcome normal
regulatory pathways that limit their numbers and their migration. The evasion of programmed …

The role of annexins in tumour development and progression

S Mussunoor, GI Murray - The Journal of Pathology: A Journal …, 2008 - Wiley Online Library
The annexins are a super‐family of closely related calcium and membrane‐binding proteins.
They have a diverse range of cellular functions that include vesicle trafficking, cell division …

Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia

S McArthur, E Cristante, M Paterno… - The Journal of …, 2010 - journals.aai.org
The brain microenvironment is continuously monitored by microglia with the detection of
apoptotic cells or pathogens being rapidly followed by their phagocytosis to prevent …

Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

G Giannini, W Cabri, C Fattorusso… - Future medicinal …, 2012 - Taylor & Francis
Histone deacetylase inhibitors (HDACis) are one of the last frontiers in pharmaceutical
research. Several classes of HDACi have been identified. Although more than 20 HDACi are …

Molecular markers in oral epithelial dysplasia

G Pitiyage, WM Tilakaratne, M Tavassoli… - Journal of oral …, 2009 - Wiley Online Library
The clinical and histologic features alone cannot accurately predict whether potentially
malignant disorders of the oral mucosa remain stable, regress or progress to malignancy …

Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells

M de Graauw, MH van Miltenburg… - Proceedings of the …, 2010 - National Acad Sciences
Annexin A1 (AnxA1) is a candidate regulator of the epithelial-to mesenchymal (EMT)-like
phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 …

Annexin-A1–a blessing or a curse in cancer?

SL Foo, G Yap, J Cui, LHK Lim - Trends in molecular medicine, 2019 - cell.com
Annexin-A1 (ANXA1), a potent endogenous immunomodulatory protein has been implicated
in multiple functions essential in cancer, including cell proliferation, apoptosis …

Potential role of Anxa1 in cancer

C Guo, S Liu, MZ Sun - Future oncology, 2013 - Taylor & Francis
The annexins are a well-known, closely related, multigene superfamily of Ca2+-regulated,
phospholipid-dependent, membrane-binding proteins. As a member of the annexins, Anxa1 …