Many genes and molecules that drive tissue patterning during organogenesis and tissue
regeneration have been discovered. Yet, we still lack a full understanding of how these …

The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Although many vertebrate organs, such as kidneys, lungs and liver, are composed of
epithelial tubules, little is known of the mechanisms that establish the length or diameter of …

This review focuses on the tissue/planar cell polarity (PCP) pathway and its role in
generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates …

Compared to normal cells, cancer cells require more energy supply during proliferation and
metabolism. In living cells, in addition to mitochondria, lipid droplets are also an important …

Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the
accumulation of cysts in the renal parenchyma and progressive decline in renal function …

The evolutionarily conserved and developmentally important Wnt signaling pathway has
traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/β …

Rotational movement of the node cilia generates a leftward fluid flow in the mouse embryo
because the cilia are posteriorly tilted,. However, it is not known how anterior-posterior …

This article considers the role played by a core set of" dynamical patterning modules"(DPMs)
in the origination, development and evolution of complex organisms. These consist of the …

The planar cell polarity (PCP) signalling pathway is essential for embryonic development
because it governs diverse cellular behaviours, and'core PCP'proteins, such as Dishevelled …