The neurobiology of stress: from serendipity to clinical relevance

BS McEwen - Brain research, 2000 - Elsevier
The hormones and other physiological agents that mediate the effects of stress on the body
have protective and adaptive effects in the short run and yet can accelerate pathophysiology …

Stress and hippocampal plasticity

BS McEwen - Annual review of neuroscience, 1999 - annualreviews.org
▪ Abstract The hippocampus is a target of stress hormones, and it is an especially plastic and
vulnerable region of the brain. It also responds to gonadal, thyroid, and adrenal hormones …

The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease

SM Korte, JM Koolhaas, JC Wingfield… - … & Biobehavioral Reviews, 2005 - Elsevier
Why do we get the stress-related diseases we do? Why do some people have flare ups of
autoimmune disease, whereas others suffer from melancholic depression during a stressful …

Effects of adverse experiences for brain structure and function

BS McEwen - Biological psychiatry, 2000 - Elsevier
Studies of the hippocampus as a target of stress and stress hormones have revealed a
considerable degree of structural plasticity in the adult brain. Repeated stress causes …

Chronic stress alters synaptic terminal structure in hippocampus

AM Magariños, JMG Verdugo… - Proceedings of the …, 1997 - National Acad Sciences
Repeated psychosocial or restraint stress causes atrophy of apical dendrites in CA3
pyramidal neurons of the hippocampus, accompanied by specific cognitive deficits in spatial …

Cellular and subcellular distribution of the serotonin 5‐HT2A receptor in the central nervous system of adult rat

V Cornea‐Hébert, M Riad, C Wu… - Journal of …, 1999 - Wiley Online Library
Light and electron microscope immunocytochemistry with a monoclonal antibody against the
N‐terminal domain of the human protein was used to determine the cellular and subcellular …

Stress effects on morphology and function of the hippocampus.

BS McEWEN, AM Magarinos - Annals of the New York Academy of …, 1997 - europepmc.org
The hippocampal formation, which contains high levels of adrenal steroid receptors, is
vulnerable to insults such as stroke, seizures, and head trauma, and it is also sensitive and …

Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders

BS McEwen, AM Magarinos - … : Clinical and Experimental, 2001 - Wiley Online Library
The hippocampal formation, a structure involved in declarative, spatial and contextual
memory, is a particularly sensitive and vulnerable brain region to stress and stress …

The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord

BJ Schmidt, LM Jordan - Brain research bulletin, 2000 - Elsevier
Over the past 40 years, much has been learned about the role of serotonin in spinal cord
reflex modulation and locomotor pattern generation. This review presents an historical …

Brain structures and neurotansmitters regulating aggression in cats: implications for human aggression

TR Gregg, A Siegel - Progress in neuro-psychopharmacology and …, 2001 - Elsevier
Violence and aggression are major public health problems. 2. The authors have used
techniques of electrical brain stimulation, anatomical-immunohistochemical techniques, and …