HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance

RW Shafer, SY Rhee, D Pillay, V Miller, P Sandstrom… - Aids, 2007 - journals.lww.com
Objectives: Monitoring regional levels of transmitted HIV-1 resistance informs treatment
guidelines and provides feedback on the success of HIV-1 prevention efforts. Surveillance …

[PDF][PDF] European recommendations for the clinical use of HIV drug resistance testing: 2011 update

AM Vandamme, RJ Camacho, F Ceccherini-Silberstein… - Aids Rev, 2011 - academia.edu
Abstract The European HIV Drug Resistance Guidelines Panel, established to make
recommendations to clinicians and virologists, felt that sufficient new information has …

Web resources for HIV type 1 genotypic-resistance test interpretation

TF Liu, RW Shafer - Clinical infectious diseases, 2006 - academic.oup.com
Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic
drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1 …

The HIVdb system for HIV-1 genotypic resistance interpretation

MW Tang, TF Liu, RW Shafer - Intervirology, 2012 - karger.com
Abstract The Stanford HIV Drug Resistance Database hosts a freely available online
genotypic resistance interpretation system called HIVdb to help clinicians and laboratories …

Two-steps learning of Fuzzy Cognitive Maps for prediction and knowledge discovery on the HIV-1 drug resistance

G Nápoles, I Grau, R Bello, R Grau - Expert Systems with Applications, 2014 - Elsevier
Abstract The Human Immunodeficiency Virus (HIV) is a complex retrovirus that progressively
deteriorates the immune system of infected patients, eventually causing death. Although …

Updated European recommendations for the clinical use of HIV drug resistance testing

AM Vandamme, A Sönnerborg, M Ait-Khaled… - Antiviral …, 2004 - journals.sagepub.com
In most European countries, HIV drug resistance testing has become a routine clinical tool.
However, its practical implementation in a clinical context is demanding. The European HIV …

Estimating HIV evolutionary pathways and the genetic barrier to drug resistance

N Beerenwinkel, M Däumer, T Sing… - The Journal of …, 2005 - academic.oup.com
Background The evolution of drug-resistant viruses challenges the management of human
immunodeficiency virus (HIV) infections. Understanding this evolutionary process is …

Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are …

J Snoeck, R Kantor, RW Shafer… - Antimicrobial agents …, 2006 - Am Soc Microbiol
The major limitation of drug resistance genotyping for human immunodeficiency virus
remains the interpretation of the results. We evaluated the concordance in predicting therapy …

Synthesis and biological evaluation of novel indole-derived thioureas

G Sanna, S Madeddu, G Giliberti, S Piras, M Struga… - Molecules, 2018 - mdpi.com
A series of 2-(1 H-indol-3-yl) ethylthiourea derivatives were prepared by condensation of 2-
(1 H-indol-3-yl) ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media …

Consensus drug resistance mutations for epidemiological surveillance: basic principles and potential controversies

RW Shafer, SY Rhee, DE Bennett - Antiviral therapy, 2008 - journals.sagepub.com
Programmes that monitor local, national and regional levels of transmitted HIV-1 drug
resistance inform treatment guidelines and provide feedback on the success of HIV-1 …