Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs
P Tran, YC Pyo, DH Kim, SE Lee, JK Kim, JS Park - Pharmaceutics, 2019 - mdpi.com
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …
reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic …
[HTML][HTML] Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions
The treatment of cancer is still a major challenge. But tremendous progress in anticancer
drug discovery and development has occurred in the last few decades. However, this …
drug discovery and development has occurred in the last few decades. However, this …
Enhanced dissolution of luteolin by solid dispersion prepared by different methods: physicochemical characterization and antioxidant activity
S Alshehri, SS Imam, MA Altamimi, A Hussain… - ACS …, 2020 - ACS Publications
Luteolin (LT) is a poorly soluble bioactive compound that suffered bioavailability problems
after oral administration. Hence, the aim of the proposed research work was to formulate and …
after oral administration. Hence, the aim of the proposed research work was to formulate and …
Evaluation of a temperature-responsive magnetotocosome as a magnetic targeting drug delivery system for sorafenib tosylate anticancer drug
F Razmimanesh, G Sodeifian - Heliyon, 2023 - cell.com
In this investigation, a polymeric fusion of chitosan (CS) and thermosensitive poly (N-
isopropyl acrylamide)-PNIPAAm-encapsulated a magnetotocosome, biocompatible …
isopropyl acrylamide)-PNIPAAm-encapsulated a magnetotocosome, biocompatible …
Microfluidic fabrication and characterization of Sorafenib-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery
Lipid polymer hybrid nanoparticles (LPHNPs) have been merged as potential nanocarriers
for treatment of cancer. In the present study, LPHNPs loaded with Sorafenib (SFN) were …
for treatment of cancer. In the present study, LPHNPs loaded with Sorafenib (SFN) were …
Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro …
Sorafenib tosylate (SFNT) is the first-line drug for hepatocellular carcinoma. It exhibits poor
solubility leading to low oral bioavailability subsequently requiring intake of large quantities …
solubility leading to low oral bioavailability subsequently requiring intake of large quantities …
Design and characterisation of novel Sorafenib-loaded carbon nanotubes with distinct tumour-suppressive activity in hepatocellular carcinoma
Purpose Over the past 30 years, no consistent survival benefits have been recorded for
anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase …
anticancer agents of advanced hepatocellular carcinoma (HCC), except for the multikinase …
Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo
Y Zeng, S Li, C Liu, T Gong, X Sun, Y Fu… - Acta Pharmacologica …, 2017 - nature.com
Scopoletin is an active coumarin possessing a variety of pharmacological activities,
including anti-hyperuricemic effect, but with poor solubility. To improve its oral bioavailability …
including anti-hyperuricemic effect, but with poor solubility. To improve its oral bioavailability …
Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability
K Van Nguyen, TK Dang, LTD Vu, NT Ha… - Journal of …, 2023 - Springer
Purpose Loratadine (LOR), a commonly prescribed antihistamine, has low water solubility
but high permeability. In this study, an orodispersible film incorporating the nanoparticulate …
but high permeability. In this study, an orodispersible film incorporating the nanoparticulate …
Hyperbranched Copolymers of Methacrylic Acid and Lauryl Methacrylate HP (MAA-co-LMA): Synthetic Aspects and Interactions with Biorelevant Compounds
A Balafouti, S Pispas - Pharmaceutics, 2023 - mdpi.com
The synthesis of novel copolymers using one-step reversible addition-fragmentation chain
transfer (RAFT) copolymerization of biocompatible methacrylic acid (MAA), lauryl …
transfer (RAFT) copolymerization of biocompatible methacrylic acid (MAA), lauryl …