Compaction mode of chromatin and chromatin highly organised structures regulate gene
expression. Posttranslational modifications, histone variants and chromatin remodelers …

Background Single nucleotide polymorphism (SNP) arrays for domestic cattle have
catalyzed the identification of genetic markers associated with complex traits for inclusion in …

Somatic cells and pluripotent cells display remarkable differences in most aspects of cell
function. Accordingly, somatic cell reprogramming by exogenous factors requires …

Hepatocellular carcinoma (HCC) is one of the most common human malignancies
worldwide with very poor prognosis. Resistance to targeted therapeutic drugs such as …

DNA damage triggers chromatin remodeling by mechanisms that are poorly understood.
The oncogene and chromatin remodeler ALC1/CHD1L massively decompacts chromatin in …

Abstract Background PBX homeobox 1 (PBX1) is involved in the maintenance of the
pluripotency of human embryonic and hematopoietic stem cells; however, the effects of …

CHD1L functions as an ATP-dependent chromatin remodeling enzyme, featuring an ATPase
catalytic domain activated by double-stranded DNA. Its involvement in critical aspects of …

The differentiation of embryonic stem cells (ESCs) into a lineage-committed state is a
dynamic process involving changes in cellular metabolism, epigenetic modifications, post …

The synthetic lethal association between BRCA deficiency and poly (ADP-ribose)
polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA …

Histone variants confer chromatin unique properties. They have specific genomic
distribution, regulated by specific deposition and removal machineries. Histone variants …