Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future
D Akhoundova, MA Rubin - Cancer Cell, 2022 - cell.com
Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …
through the identification of therapeutic targets and molecular biomarkers, leading to the …
[HTML][HTML] Recent advances in the field of single-cell proteomics
V Petrosius, EM Schoof - Translational oncology, 2023 - Elsevier
The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-
based methods have dominated the field to date, global proteome profiling has also entered …
based methods have dominated the field to date, global proteome profiling has also entered …
Kg-mtl: knowledge graph enhanced multi-task learning for molecular interaction
Molecular interaction prediction is essential in various applications including drug discovery
and material science. The problem becomes quite challenging when the interaction is …
and material science. The problem becomes quite challenging when the interaction is …
[HTML][HTML] Recent advances in kinase signaling network profiling by mass spectrometry
Mass spectrometry-based phosphoproteomics is currently the leading methodology for the
study of global kinase signaling. The scientific community is continuously releasing …
study of global kinase signaling. The scientific community is continuously releasing …
Spatial-omics technologies: the new enterprise in 3D breast cancer models
The fields of tissue bioengineering,-omics, and spatial biology are advancing rapidly, each
offering the opportunity for a paradigm shift in breast cancer research. However, to date …
offering the opportunity for a paradigm shift in breast cancer research. However, to date …
Combination of multiple omics techniques for a personalized therapy or treatment selection
C Massa, B Seliger - Frontiers in Immunology, 2023 - frontiersin.org
Despite targeted therapies and immunotherapies have revolutionized the treatment of
cancer patients, only a limited number of patients have long-term responses. Moreover, due …
cancer patients, only a limited number of patients have long-term responses. Moreover, due …
Elucidating Fibroblast Growth Factor–Induced Kinome Dynamics Using Targeted Mass Spectrometry and Dynamic Modeling
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that, activated
by their ligands, elicit a wide range of health and disease-related processes, such as cell …
by their ligands, elicit a wide range of health and disease-related processes, such as cell …
[HTML][HTML] N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
A genome-wide PiggyBac transposon-mediated screen and a resistance screen in a
PIK3CA H1047R-mutated murine tumor model reveal NF1 loss in mammary tumors resistant …
PIK3CA H1047R-mutated murine tumor model reveal NF1 loss in mammary tumors resistant …
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities
T Pemovska, JW Bigenzahn, I Srndic, A Lercher… - Nature …, 2021 - nature.com
Interrogation of cellular metabolism with high-throughput screening approaches can unravel
contextual biology and identify cancer-specific metabolic vulnerabilities. To systematically …
contextual biology and identify cancer-specific metabolic vulnerabilities. To systematically …
The 2023 report on the proteome from the HUPO human proteome project
Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human
Proteome Organization (HUPO), has pursued two goals:(1) to credibly identify the protein …
Proteome Organization (HUPO), has pursued two goals:(1) to credibly identify the protein …