Construction of antibacterial bone implants and their application in bone regeneration

P Feng, R He, Y Gu, F Yang, H Pan, C Shuai - Materials Horizons, 2024 - pubs.rsc.org
Bacterial infection represents a prevalent challenge during the bone repair process, often
resulting in implant failure. However, the extensive use of antibiotics has limited local …

3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

H Lee, G Han, Y Na, M Kang, SJ Bang… - Advanced Functional …, 2024 - Wiley Online Library
The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and
postoperative bacterial infections subsequent to the surgical removal of bone tumors have …

Adaptive Nanoparticle-Mediated Modulation of Mitochondrial Homeostasis and Inflammation to Enhance Infected Bone Defect Healing

X Chen, Q He, Q Zhai, H Tang, D Li, X Zhu, X Zheng… - ACS …, 2023 - ACS Publications
Infected bone defects (IBDs) exhibit impaired healing due to excessive inflammation
triggered by pathogen-associated molecular patterns (PAMPs) from bacteria. As a vital factor …

Engineering the Functional Expansion of Microneedles

S Yang, Y Xu, M Zhu, Y Yu, W Hu, T Zhang… - Advanced …, 2024 - Wiley Online Library
Microneedles (MNs), composed of an array of micro‐sized needles and a supporting base,
have transcended their initial use to replace hypodermic needles in drug delivery and fluid …

pH Switchable Nanozyme Platform for Healing Skin Tumor Wound Infected with Drug‐Resistant Bacteria

Y Yan, M Wang, M Zhao, J Zhang… - Advanced Healthcare …, 2023 - Wiley Online Library
Nanozymes capable of generating reactive oxygen species have recently emerged as
promising treatments for wounds infected with drug‐resistant bacteria, possessing a …

Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation …

M Wu, H Liu, Y Zhu, P Wu, Y Chen, Z Deng… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: The comprehensive management of diabetic bone defects remains a
substantial clinical challenge due to the hostile regenerative microenvironment …

A multifunctional self-reinforced injectable hydrogel for enhancing repair of infected bone defects by simultaneously targeting macrophages, bacteria, and bone …

J Du, Y Chu, Y Hu, J Liu, H Liu, H Wang, C Yang… - Acta Biomaterialia, 2024 - Elsevier
Injectable hydrogels (IHs) have demonstrated huge potential in promoting repair of infected
bone defects (IBDs), but how to endow them with desired anti-bacterial, immunoregulatory …

Self-Assembled Biofunctionalized Chitosan-Derived Nanocomposite for Long-Lasting Antibacterial Packaging at Room Temperature

J Yang, G Chen, J Chen, Y Liu, Z Yang… - ACS Sustainable …, 2023 - ACS Publications
The development of biobased antibacterial nanomaterials for normal-temperature food
preservation is important to prevent foodborne pathogenic infections and achieve low …

Multiple‐Effect Combined Hydrogels:“Temporal Regulation” Treatment of Osteosarcoma‐Associated Bone Defects with Switchable Hyperthermia and Bioactive …

L Li, Y Lin, K Liu, R Huang, W Wen… - Advanced …, 2024 - Wiley Online Library
Achieving the clinically staged treatment of osteosarcoma‐associated bone defects
encounters the multiple challenges of promptly removing postoperative residual tumor cells …

Janus silk fibroin/polycaprolactone-based scaffold with directionally aligned fibers and porous structure for bone regeneration

Z Tang, J Li, L Fu, T Xia, X Dong, H Deng… - International Journal of …, 2024 - Elsevier
To promote bone repair, it is desirable to develop three-dimensional multifunctional fiber
scaffolds. The densely stacked and tightly arranged conventional two-dimensional …