Personalised virtual brain models in epilepsy

V Jirsa, H Wang, P Triebkorn, M Hashemi… - The Lancet …, 2023 - thelancet.com
Individuals with drug-resistant focal epilepsy are candidates for surgical treatment as a
curative option. Before surgery can take place, the patient must have a presurgical …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Upper cortical layer–driven network impairment in schizophrenia

MY Batiuk, T Tyler, K Dragicevic, S Mei, R Rydbirk… - Science …, 2022 - science.org
Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …

[HTML][HTML] Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

[HTML][HTML] A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases

Y Zeighami, TE Bakken, T Nickl-Jockschat… - PLoS …, 2023 - journals.plos.org
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of …

Operative list of genes associated with autism and neurodevelopmental disorders based on database review

CS Leblond, TL Le, S Malesys, F Cliquet… - Molecular and Cellular …, 2021 - Elsevier
The genetics of neurodevelopmental disorders (NDD) has made tremendous progress
during the last few decades with the identification of more than 1,500 genes associated with …

[HTML][HTML] Neurodevelopmental disorders—high-resolution rethinking of disease modeling

K Khodosevich, CM Sellgren - Molecular Psychiatry, 2023 - nature.com
Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

[HTML][HTML] GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

S Bossi, D Dhanasobhon, GCR Ellis-Davies, J Frontera… - Neuron, 2022 - cell.com
GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions
in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits …

Firing patterns in a fractional-order FithzHugh–Nagumo neuron model

Z Yao, K Sun, S He - Nonlinear Dynamics, 2022 - Springer
Various neuron models and circuits have been developed to explore how neurons detect
and encode different stimuli. However, relevant researches failed to consider edge effects …

Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling

S Bossi, L Pizzamiglio, P Paoletti - Trends in Neurosciences, 2023 - cell.com
GluN3A is a glycine-binding subunit belonging to the NMDA receptor (NMDAR) family that
can assemble with GluN1 subunits to form unconventional NMDARs insensitive to glutamate …