The production of recombinant pharmaceutical proteins in plants

JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …

Molecular farming in plants: host systems and expression technology

RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …

Domain antibodies: proteins for therapy

LJ Holt, C Herring, LS Jespers, BP Woolven… - TRENDS in …, 2003 - cell.com
Occurring naturally in 'heavy chain'immunoglobulins from camels, and now produced in fully
human form, domain antibodies (dAbs) are the smallest known antigen-binding fragments of …

Tomato (Solanum lycopersicum) health components: from the seed to the consumer

M Dorais, DL Ehret, AP Papadopoulos - Phytochemistry Reviews, 2008 - Springer
It is widely accepted that a healthy diet is an important factor in preventing chronic diseases,
and in improving energy balance and weight management. Studies have shown strong …

Generation of glyco‐engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human‐like N‐glycan structure

R Strasser, J Stadlmann, M Schähs… - Plant biotechnology …, 2008 - Wiley Online Library
A common argument against using plants as a production system for therapeutic proteins is
their inability to perform authentic human N‐glycosylation (ie the presence of β1, 2 …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Plastid transformation in higher plants

P Maliga - Annu. Rev. Plant Biol., 2004 - annualreviews.org
▪ Abstract Plastids of higher plants are semi-autonomous organelles with a small, highly
polyploid genome and their own transcription-translation machinery. This review provides …

Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures

J Xu, X Ge, MC Dolan - Biotechnology advances, 2011 - Elsevier
“Molecular farming” in plants with significant advantages in cost and safety is touted as a
promising platform for the production of complex pharmaceutical proteins. While whole-plant …

Plants as bioreactors: recent developments and emerging opportunities

AK Sharma, MK Sharma - Biotechnology advances, 2009 - Elsevier
In recent years, the use of plants as bioreactors has emerged as an exciting area of research
and significant advances have created new opportunities. The driving forces behind the …

Plant molecular farming: systems and products

ME Horn, SL Woodard, JA Howard - Plant cell reports, 2004 - Springer
Plant molecular farming is a new and promising industry involving plant biotechnology. In
this review, we describe several diverse plant systems that have been developed to produce …