Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes
HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …
successfully translated to the clinic. Increased importance on the progressive, long-term …
[HTML][HTML] Quantitating the subtleties of microglial morphology with fractal analysis
A Karperien, H Ahammer, HF Jelinek - Frontiers in cellular …, 2013 - frontiersin.org
It is well established that microglial form and function are inextricably linked. In recent years,
the traditional view that microglial form ranges between “ramified resting” and “activated …
the traditional view that microglial form ranges between “ramified resting” and “activated …
Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba‐1 or GFAP immunoreactivity following systemic immune challenge
Activation of the peripheral immune system elicits a coordinated response from the central
nervous system. Key to this immune to brain communication is that glia, microglia, and …
nervous system. Key to this immune to brain communication is that glia, microglia, and …
β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat
Psychosocial stress is associated with altered immune function and development of
psychological disorders including anxiety and depression. Here we show that repeated …
psychological disorders including anxiety and depression. Here we show that repeated …
TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation
While there clearly is an intimate relationship between astrocytes and microglia, few studies
have examined these potentially dynamic interactions. In this study, cytokine‐mediated …
have examined these potentially dynamic interactions. In this study, cytokine‐mediated …
Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain
Background Persistent anxiety-like symptoms may have an inflammatory-related
pathophysiology. Our previous work using repeated social defeat (RSD) in mice showed that …
pathophysiology. Our previous work using repeated social defeat (RSD) in mice showed that …
[HTML][HTML] Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
C Perego, S Fumagalli, MG De Simoni - Journal of neuroinflammation, 2011 - Springer
Background Emerging evidence indicates that, similarly to what happens for peripheral
macrophages, microglia can express different phenotypes depending on …
macrophages, microglia can express different phenotypes depending on …
Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia
Background Traumatic brain injury (TBI) is associated with a higher incidence of depression.
The majority of individuals who suffer a TBI are juveniles and young adults, and thus, the risk …
The majority of individuals who suffer a TBI are juveniles and young adults, and thus, the risk …
Neuroinflammatory dynamics underlie memory impairments after repeated social defeat
Repeated social defeat (RSD) is a murine stressor that recapitulates key physiological,
immunological, and behavioral alterations observed in humans exposed to chronic …
immunological, and behavioral alterations observed in humans exposed to chronic …
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in …
Repeated social defeat (RSD) activates neuroendocrine pathways that have a significant
influence on immunity and behavior. Previous studies from our lab indicate that RSD …
influence on immunity and behavior. Previous studies from our lab indicate that RSD …