Are all granzymes cytotoxic in vivo?
LT Joeckel, PI Bird - Biological chemistry, 2014 - degruyter.com
Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …
Orphan granzymes find a home
N Bovenschen, JA Kummer - Immunological reviews, 2010 - Wiley Online Library
Cytotoxic lymphocytes are armed with granules that are released in the granule‐exocytosis
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore …
pathway to kill tumor cells and virus‐infected cells. Cytotoxic granules contain the pore …
Solvation free energy as a measure of hydrophobicity: application to serine protease binding interfaces
Solvation and hydrophobicity play a key role in a variety of biological mechanisms. In
substrate binding, but also in structure-based drug design, the thermodynamic properties of …
substrate binding, but also in structure-based drug design, the thermodynamic properties of …
Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site
Abstract γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid
precursor protein (APP) involved in Alzheimer's disease pathology and other …
precursor protein (APP) involved in Alzheimer's disease pathology and other …
Structural and dynamic determinants of protein-peptide recognition
Protein-peptide interactions play important roles in many cellular processes, including signal
transduction, trafficking, and immune recognition. Protein conformational changes upon …
transduction, trafficking, and immune recognition. Protein conformational changes upon …
Noncytotoxic roles of granzymes in health and disease
KC Richardson, K Jung, J Pardo, CT Turner… - …, 2022 - journals.physiology.org
Granzymes are serine proteases previously believed to play exclusive and somewhat
redundant roles in lymphocyte-mediated target cell death. However, recent studies have …
redundant roles in lymphocyte-mediated target cell death. However, recent studies have …
Human and mouse granzyme M display divergent and species-specific substrate specificities
SAH de Poot, M Westgeest, DR Hostetter… - Biochemical …, 2011 - portlandpress.com
Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death
and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) …
and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) …
Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein
The granule exocytosis pathway of cytotoxic lymphocytes plays critical roles in eradication of
intracellular viruses. However, how hepatitis B virus (HBV) is cleared has not been defined …
intracellular viruses. However, how hepatitis B virus (HBV) is cleared has not been defined …
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to …
Granzyme M (GzmM) is a chymotrypsin-like serine protease that preferentially cuts its
substrates after Met or Leu. GzmM is constitutively expressed in activated innate effector …
substrates after Met or Leu. GzmM is constitutively expressed in activated innate effector …
FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade
S Wang, P Xia, L Shi, Z Fan - Cell Death & Differentiation, 2012 - nature.com
Granzyme M (GzmM), an orphan Gzm, is constitutively and abundantly expressed in innate
effector natural killer cells. We previously demonstrated that GzmM induces caspase (casp) …
effector natural killer cells. We previously demonstrated that GzmM induces caspase (casp) …