β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

In this review, we summarize the current “state of the art” of carbapenem antibiotics and their
role in our antimicrobial armamentarium. Among the β-lactams currently available …

Despite having a reputation of low virulence, Acinetobacter baumannii is an emerging
multidrug-resistant (MDR) pathogen responsible for community-and hospital-acquired …

Unprecedented levels of antimicrobial resistance in bacterial isolates have prompted great
concerns globally. In 2012 the WHO released a publication outlining the evolving threat of …

Antimicrobial resistance poses a serious threat to control infections due to ABC. Strategies to
curtail environmental colonization with MDR-ABD will require aggressive infection control …

Objectives To investigate the mechanisms of carbapenem resistance in the 175
Pseudomonas aeruginosa isolates (39%; 175/448) showing non-susceptibility (European …

Rapid detection of carbapenem-resistant Acinetobacter baumannii strains is critical and will
benefit patient care by optimizing antibiotic therapies and preventing outbreaks. Herein we …

Intensive care unit (ICU) patients with end-organ failure will require specialised machines or
extracorporeal therapies to support the failing organs that would otherwise lead to death …

The silent pandemic of bacterial antimicrobial resistance is a leading cause of death
worldwide, prolonging hospital stays and raising health-care costs. Poor incentives to …