[HTML][HTML] Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

V Kumar, S Kundu, A Singh, S Singh - Current neuropharmacology, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Role of epigenetic mechanisms in chronic pain

D Mauceri - Cells, 2022 - mdpi.com
Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage.
When pain persists long after the injury has resolved, it becomes pathological. The precise …

Tuning mass transport in electrocatalysis down to sub‐5 nm through nanoscale grade separation

Z Liu, Y Du, R Yu, M Zheng, R Hu, J Wu… - Angewandte …, 2023 - Wiley Online Library
Nano and single‐atom catalysis open new possibilities of producing green hydrogen (H2)
by water electrolysis. However, for the hydrogen evolution reaction (HER) which occurs at a …

A signalling pathway for transcriptional regulation of sleep amount in mice

R Zhou, G Wang, Q Li, F Meng, C Liu, R Gan, D Ju… - Nature, 2022 - nature.com
In mice and humans, sleep quantity is governed by genetic factors and exhibits age-
dependent variation,–. However, the core molecular pathways and effector mechanisms that …

Phospholipase C beta 1 in the dentate gyrus gates fear memory formation through regulation of neuronal excitability

J Lee, Y Jeong, S Park, S Kim, H Oh, JA Jin… - Science …, 2024 - science.org
Memory processes rely on a molecular signaling system that balances the interplay between
positive and negative modulators. Recent research has focused on identifying memory …

Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy

M Zhou, M Yuan, M Zhang, C Lei, O Aras… - European journal of …, 2021 - Elsevier
Histone deacetylases (HDACs) play an important role in regulating the expression of genes
involved in tumorigenesis and tumor maintenance, and hence they have been considered …

Activity-dependent transcriptional programs in memory regulate motor recovery after stroke

MT Joy, ST Carmichael - Communications Biology, 2024 - nature.com
Stroke causes death of brain tissue leading to long-term deficits. Behavioral evidence from
neurorehabilitative therapies suggest learning-induced neuroplasticity can lead to beneficial …

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

W Wei, Q Zhao, Z Wang, WS Liau, D Basic, H Ren… - Cell reports, 2022 - cell.com
Here, we used RNA capture-seq to identify a large population of lncRNAs that are
expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related …

Kinase signalling in excitatory neurons regulates sleep quantity and depth

SJ Kim, N Hotta-Hirashima, F Asano, T Kitazono… - Nature, 2022 - nature.com
Progress has been made in the elucidation of sleep and wakefulness regulation at the
neurocircuit level,. However, the intracellular signalling pathways that regulate sleep and the …

The epigenetics of migraine

F Zobdeh, II Eremenko, MA Akan, VV Tarasov… - International Journal of …, 2023 - mdpi.com
Migraine is a complex neurological disorder and a major cause of disability. A wide range of
different drug classes such as triptans, antidepressants, anticonvulsants, analgesics, and …