New and emerging oral/topical small-molecule treatments for psoriasis

E Carmona-Rocha, L Rusiñol, L Puig - Pharmaceutics, 2024 - mdpi.com
The introduction of biologic therapies has led to dramatic improvements in the management
of moderate-to-severe psoriasis. Even though the efficacy and safety of the newer biologic …

Emerging Oral Therapies for the Treatment of Psoriasis: A Review of Pipeline Agents

A Drakos, T Torres, R Vender - Pharmaceutics, 2024 - mdpi.com
The introduction of biologic agents for the treatment of psoriasis has revolutionized the
current treatment landscape, targeting cytokines in the interleukin (IL)-23/IL-17 pathway and …

Clinical pharmacokinetics and pharmacodynamics of oral systemic nonbiologic therapies for psoriasis patients

JM Eichinger, DM Shan, JD Greenzaid… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Psoriasis is a chronic inflammatory immune condition. Treatments for psoriasis
vary with disease severity, ranging from topicals to systemic biologic agents. The …

New and emerging oral therapies for psoriasis

O Yilmaz, JP Pinto, T Torres - Drugs in Context, 2024 - pmc.ncbi.nlm.nih.gov
Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the global population.
Traditional systemic treatments, such as methotrexate, cyclosporine, acitretin and fumaric …

Baseline Characteristics and Maintenance Therapy Choice on Symptom Control, Reliever Use, Exacerbation Risk in Moderate–Severe Asthma: A Clinical Modelling …

P Paggiaro, G Garcia, N Roche, M Verma, M Plank… - Advances in …, 2024 - Springer
Introduction Although some factors associated with asthma symptom deterioration and risk
of exacerbation have been identified, these are not yet fully characterised. We conducted a …

Cost per response analysis of deucravacitinib versus apremilast and first-line biologics among patients with moderate to severe plaque psoriasis in the United States

SH Park, M Lambton, J Schmier… - Journal of …, 2024 - Taylor & Francis
Background Understanding the economic value of deucravacitinib and apremilast could
assist treatment decision-making for patients with moderate to severe plaque psoriasis …

Efficacy and safety of deucravacitinib for the management of psoriasis: a drug safety evaluation

L Potestio, N Tommasino, G Lauletta… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Nowadays, despite the wide availability of biological drugs and apremilast for
psoriasis management, there is always a need for new therapies to customize the …

Dual‐Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self‐Locking Microneedles

ZY Wang, ZQ Zhao, YJ Sheng, KJ Chen… - Advanced …, 2024 - Wiley Online Library
Psoriasis is a chronic, immune‐mediated disorder characterized by immune regulation
disorders and abnormal keratinocyte proliferation. Deucravacitinib (Deu), a selective oral …

Matching-Adjusted Indirect Comparison of Risankizumab Versus Deucravacitinib in Patients with Moderate-to-Severe Plaque Psoriasis

AW Armstrong, AM Soliman, P Gisondi, S Fang… - Dermatology and …, 2024 - Springer
Methods This placebo-anchored matching-adjusted indirect comparison (MAIC) analysis
utilized data from UltIMMa-1/2 risankizumab and POETYK PSO-1/2 deucravacitinib trials …

Indirect comparison of deucravacitinib and other systemic treatments for moderate to severe plaque psoriasis in Asian populations: A systematic literature review and …

TF Tsai, Y Tada, C Kung, Y Zhong… - The Journal of …, 2024 - Wiley Online Library
Expanding the systemic treatment options for patients with psoriasis, deucravacitinib, an
oral, selective, allosteric tyrosine kinase 2 inhibitor is approved in the United States …