Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

The role of extracellular vesicles in the hallmarks of cancer and drug resistance

CPR Xavier, HR Caires, MAG Barbosa, R Bergantim… - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the
intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the …

[HTML][HTML] Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer

Y Wang, Y Li, J Zhong, M Li, Y Zhou, Q Lin, S Zong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Abstract Rationale: Breast cancer (BC), as one of the most frequently diagnosed cancer, has
a poor prognosis due to the development of distant metastasis. Among the BC metastatic …

[HTML][HTML] Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression

G Xu, B Zhang, J Ye, S Cao, J Shi, Y Zhao… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Solid tumors consist of various types of stromal cells in addition to cancer cells. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and play an …

Lipid rafts in exosome biogenesis

GO Skryabin, AV Komelkov, EE Savelyeva… - Biochemistry …, 2020 - Springer
Exosomes (secreted extracellular vesicles formed in the intracellular vesicular transport
system) play a crucial role in distant cell–cell communication. Exosomes transfer active …

Pioneer role of extracellular vesicles as modulators of cancer initiation in progression, drug therapy, and vaccine prospects

S Jahan, S Mukherjee, S Ali, U Bhardwaj… - Cells, 2022 - mdpi.com
Cancer is one of the leading diseases, causing deaths worldwide. Nearly 10 million deaths
were reported in 2020 due to cancer alone. Several factors are involved in cancer …

Potential role of exosomes in cancer metastasis

W Tian, S Liu, B Li - BioMed research international, 2019 - Wiley Online Library
High cancer mortality is attributed to metastasis to a large extent. However, cancer
metastasis remains devoid of dynamic monitoring and early prevention in terms of current …

The biology of exosomes in breast cancer progression: dissemination, immune evasion and metastatic colonization

C Giordano, G La Camera, L Gelsomino, I Barone… - Cancers, 2020 - mdpi.com
In recent decades, the study of exosome biology has gained growing interest, representing
an active area of cancer research with many potential clinical applications. Exosomes are …

[HTML][HTML] Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic …

DX Zhang, LT Vu, NN Ismail, MTN Le… - Seminars in cancer …, 2021 - Elsevier
Extracellular vesicles (EVs) are increasingly recognised as a pivotal player in cell-cell
communication, an attribute of EVs that derives from their ability to transport bioactive …

[HTML][HTML] Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer

L Simón, A Campos, L Leyton, AFG Quest - Cancer and Metastasis …, 2020 - Springer
Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for
instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular …