Acute bacterial meningitis : Current Opinion in Neurology Acute bacterial meningitis :
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …

In environments characterized by extended multi-stress conditions, pathogens develop a
variety of immune escape mechanisms to enhance their ability to infect the host. The …

Pneumolysin (PLY) is a pore-forming toxin produced by the human pathobiont
Streptococcus pneumoniae, the major cause of pneumonia worldwide. PLY, a key …

Bacterial meningitis is a serious central nervous system (CNS) infection, claiming millions of
human lives annually around the globe. The deadly infection involves severe inflammation …

Microglia are highly dynamic in the brain in terms of their ability to migrate, proliferate, and
phagocytose over the course of an individual's life. Real-time imaging is a useful tool to …

Bacterial meningitis is a catastrophic nervous system disorder with high mortality and wide
range of morbidities. Some of the meningitis-causing bacteria occupy cholesterol dependent …

Background: The brain is protected from invading pathogens by the blood− brain barrier
(BBB) and the innate immune system. Pattern recognition receptors play a crucial role in …

Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis
and meningoencephalitis in humans. The bacterium produces numerous virulence …

In pneumococcal meningitis, bacterial growth in the cerebrospinal fluid results in lysis, the
release of toxic factors, and subsequent neuroinflammation. Exposure of primary murine glia …

A major Streptococcus pneumoniae pathogenic factor is the cholesterol-dependent cytolysin
pneumolysin, binding membrane cholesterol and producing permanent lytic or transient …