The accurate quantitation of proteins and peptides in complex biological systems is one of
the most challenging areas of proteomics. Mass spectrometry‐based approaches have …

Proteomics is the large-scale study of proteins, particularly their expression, structures and
functions. This still-emerging combination of technologies aims to describe and characterize …

Inflammation is a major factor underlying acute coronary syndromes (ACS). HDL particles
may be remodeled, becoming functionally defective, under the inflammatory conditions seen …

Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly
correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease (AD) brain and …

The precise quantification of changes between various physiological states in a biological
system is highly complex in nature. Over the past few years, in combination with classical …

Introduction Alzheimer's disease (AD) is the most common cause of dementia, characterized
by progressive cognitive decline. Protein biomarkers of AD brain pathology, including β …

Nonalcoholic fatty liver disease (NAFLD), ranging from relatively benign simple steatosis to
progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common …

Normalized spectral index quantification was recently presented as an accurate method of
label‐free quantitation, which improved spectral counting by incorporating the intensities of …

Background Following amputation, urodele salamander limbs reprogram somatic cells to
form a blastema that self-organizes into the missing limb parts to restore the structure and …

Background Spectral counting methods provide an easy means of identifying proteins with
differing abundances between complex mixtures using shotgun proteomics data. The crux …