Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies

CW Pouton, CJH Porter - Advanced drug delivery reviews, 2008 - Elsevier
Oral lipid-based drug delivery systems may include a broad range of oils, surfactants, and
cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although …

Nanoemulsion-and emulsion-based delivery systems for curcumin: Encapsulation and release properties

K Ahmed, Y Li, DJ McClements, H Xiao - Food chemistry, 2012 - Elsevier
Curcumin has been reported to have many biological activities, but its application as a
functional ingredient is currently limited because of its poor water-solubility and …

Nanoemulsion delivery systems for oil-soluble vitamins: Influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility

B Ozturk, S Argin, M Ozilgen, DJ McClements - Food chemistry, 2015 - Elsevier
The influence of carrier oil type on the bioaccessibility of vitamin D 3 encapsulated within oil-
in-water nanoemulsions prepared using a natural surfactant (quillaja saponin) was studied …

Challenges and solutions for the delivery of biotech drugs–a review of drug nanocrystal technology and lipid nanoparticles

RH Muller, CM Keck - Journal of biotechnology, 2004 - Elsevier
Biotechnology allows tailor-made production of biopharmaceuticals and biotechnological
drugs; however, many of them require special formulation technologies to overcome drug …

Review of in vitro digestion models for rapid screening of emulsion-based systems

DJ McClements, Y Li - Food & function, 2010 - pubs.rsc.org
There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …

Enhancing intestinal drug solubilisation using lipid-based delivery systems

CJH Porter, CW Pouton, JF Cuine… - Advanced drug delivery …, 2008 - Elsevier
Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …

Modulating fat digestion through food structure design

Q Guo, A Ye, N Bellissimo, H Singh… - Progress in Lipid …, 2017 - Elsevier
Dietary fats and oils are an important component of our diet and a significant contributor to
total energy and intake of lipophilic nutrients and bioactives. We discuss their fate in a wide …

Lipid–an emerging platform for oral delivery of drugs with poor bioavailability

S Chakraborty, D Shukla, B Mishra, S Singh - European journal of …, 2009 - Elsevier
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …

Stable drug encapsulation in micelles and microemulsions

AS Narang, D Delmarre, D Gao - International journal of pharmaceutics, 2007 - Elsevier
Oral absorption of hydrophobic drugs can be significantly improved using lipid-based non-
particulate drug delivery systems, which avoid the dissolution step. Micellar and …