An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

For tumors to progress efficiently, cancer cells must overcome barriers of oxidative stress.
Although dietary antioxidant supplementation or activation of endogenous antioxidants by …

Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …

Excessive cellular oxidative stress is widely perceived as a key factor in pathophysiological
conditions and cancer development. Healthy cells use several mechanisms to maintain …

Antioxidants are widely used to protect cells from damage induced by reactive oxygen
species (ROS). The concept that antioxidants can help fight cancer is deeply rooted in the …

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on
the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of …

Head and neck cancer is among the top ten cancers worldwide, with most lesions in the oral
cavity. Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Reactive oxygen species (ROS) are highly reactive molecules that arise from a number of
cellular sources, including oxidative metabolism in mitochondria. At low levels they can be …