Autoinflammatory diseases are conditions in which pathogenic inflammation arises primarily
through antigen-independent hyperactivation of immune pathways. First recognized just …

Mendelian autoinflammatory diseases characterized by constitutive activation of the type I
interferon pathway, the so-called type I interferonopathies, constitute a rapidly expanding …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

This article provides an initial assessment of the many risks posed by the COVID-19
pandemic on the conduct of genuine and transparent elections in the world. It begins with …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlapping clinically with type I IFN-mediated disease due to gain-of-function in STING, a …

Objective Autoinflammatory type I interferonopathies, chronic atypical neutrophilic
dermatosis with lipodystrophy and elevated temperature/proteasome-associated …

Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …

A number of systemic autoinflammatory diseases arise from gain-of-function mutations in
genes encoding IL-1–activating inflammasomes or cytoplasmic nucleic acid sensors …

Objective This study aimed to assess the efficacy and safety of 2 Janus kinase (JAK)
inhibitors (jakinibs) tofacitinib and ruxolitinib in the treatment of type I interferonopathies …

Gain-of-function mutations in STING cause STING-associated vasculopathy with onset in
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …