Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy

Q Jin, KY Lee, Z Selimi, D Shimura, E Wang… - Journal of molecular and …, 2024 - Elsevier
Gap junction and ion channel remodeling occur early in Arrhythmogenic Cardiomyopathy
(ACM), but their pathogenic consequences have not been elucidated. Here, we identified …

New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?

ZJ Williams, LB Payne, X Wu, RG Gourdie - Heart Rhythm, 2024 - Elsevier
Voltage-gated sodium channels (VGSCs) are transmembrane protein complexes that are
vital to the generation and propagation of action potentials in nerve and muscle fibers. The …

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

L Mezache, AM Soltisz, SR Johnstone… - Clinical …, 2023 - jacc.org
Background Atrial fibrillation (AF), the most common cardiac arrhythmia, is widely associated
with inflammation, vascular dysfunction, and elevated levels of the vascular leak-inducing …