Chromosomal instability—mechanisms and consequences
S Venkatesan, AT Natarajan, MP Hande - Mutation Research/Genetic …, 2015 - Elsevier
Chromosomal instability is defined as a state of numerical and/or structural chromosomal
anomalies in cells. Numerous studies have documented the incidence of chromosomal …
anomalies in cells. Numerous studies have documented the incidence of chromosomal …
[HTML][HTML] The functions of DNA damage factor RNF8 in the pathogenesis and progression of cancer
T Zhou, F Yi, Z Wang, Q Guo, J Liu, N Bai… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
The really interesting new gene (RING) finger protein 8 (RNF8) is a central factor in DNA
double strand break (DSB) signal transduction. DSB damage is the most toxic type of DNA …
double strand break (DSB) signal transduction. DSB damage is the most toxic type of DNA …
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells
C Lancini, PCM van den Berk, JHA Vissers… - Journal of Experimental …, 2014 - rupress.org
Histone ubiquitination at DNA breaks is required for activation of the DNA damage response
(DDR) and DNA repair. How the dynamic removal of this modification by deubiquitinating …
(DDR) and DNA repair. How the dynamic removal of this modification by deubiquitinating …
[HTML][HTML] Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
L Li, KKN Guturi, B Gautreau, PS Patel… - The Journal of …, 2018 - Am Soc Clin Investig
The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by
promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling …
promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling …
[HTML][HTML] RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression
T Zhou, S Wang, X Song, W Liu, F Dong, Y Huo… - Cell Death & …, 2022 - nature.com
Androgen receptor (AR) signaling drives prostate cancer (PC) progression. Androgen
deprivation therapy (ADT) is temporally effective, whereas drug resistance inevitably …
deprivation therapy (ADT) is temporally effective, whereas drug resistance inevitably …
RNF8 promotes epithelial–mesenchymal transition in lung cancer cells via stabilization of slug
J Kuang, L Min, C Liu, S Chen, C Gao, J Ma, X Wu… - Molecular Cancer …, 2020 - AACR
Abstract RNF8 (ring finger protein 8), a RING finger E3 ligase best characterized for its role
in DNA repair and sperm formation via ubiquitination, has been found to promote tumor …
in DNA repair and sperm formation via ubiquitination, has been found to promote tumor …
[HTML][HTML] Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells
S Sane, A Abdullah, DA Boudreau, RK Autenried… - Cell death & …, 2014 - nature.com
Abstract Mortalin (mot-2) induces inactivation of the tumor suppressor p53's transcriptional
and apoptotic functions by cytoplasmic sequestration of p53 in select cancers. The mot-2 …
and apoptotic functions by cytoplasmic sequestration of p53 in select cancers. The mot-2 …
[HTML][HTML] Plumbagin shows anticancer activity in human osteosarcoma (MG-63) cells via the inhibition of S-Phase checkpoints and down-regulation of c-myc
CH Yan, F Li, YC Ma - International journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Objective: Plumbagin, a naphthoquinone constituent of Plumbago zeylanica
L.(Plumbaginaceae), has been extensively studied for its pharmacological activities and …
L.(Plumbaginaceae), has been extensively studied for its pharmacological activities and …
Arene ruthenium (II) complexes induce S-phase arrest in MG-63 cells through stabilization of c-Myc G-quadruplex DNA
C Fan, Q Wu, T Chen, Y Zhang, W Zheng, Q Wang… - …, 2014 - pubs.rsc.org
A series of arene ruthenium (II) complexes coordinated by phenanthroimidazole derivatives
have been synthesized and evaluated for their in vitro anticancer activities. It has been found …
have been synthesized and evaluated for their in vitro anticancer activities. It has been found …
[HTML][HTML] Urokinase Receptor uPAR Downregulation in Neuroblastoma Leads to Dormancy, Chemoresistance and Metastasis
AA Shmakova, PS Klimovich, KD Rysenkova… - Cancers, 2022 - mdpi.com
Simple Summary uPAR is a membrane receptor that contributes to extracellular matrix
remodeling and controls cellular adhesion, proliferation, survival, and migration. We …
remodeling and controls cellular adhesion, proliferation, survival, and migration. We …