Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased
intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle …

The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

Exosomes are nanometer-sized vesicles that are released by cells in a controlled fashion
and mediate a plethora of extra-and intercellular activities. Some key functions of exosomes …

Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …

TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue
remodeling processes. Due to its many functions and cell-specific effects, the consequences …

Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd
most common cause of irreversible vision loss in the United States. Nearly 67 million people …

Primary open-angle glaucoma progression is associated with increased human trabecular
meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in …

In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells
occurs by apoptosis. This final event is preceded by inflammatory responses involving the …