Application of radiosensitizers in cancer radiotherapy

L Gong, Y Zhang, C Liu, M Zhang… - International journal of …, 2021 - Taylor & Francis
Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells
and shrink tumors. Although great success has been achieved on radiotherapy, there is still …

Cancer radiosensitizers

H Wang, X Mu, H He, XD Zhang - Trends in pharmacological sciences, 2018 - cell.com
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a
large challenge to enhance radiation damage to tumor tissue and reduce side effects to …

[HTML][HTML] Metal-based nanoenhancers for future radiotherapy: radiosensitizing and synergistic effects on tumor cells

Y Liu, P Zhang, F Li, X Jin, J Li, W Chen, Q Li - Theranostics, 2018 - ncbi.nlm.nih.gov
Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past
decade, there has been growing interest in using high Z (atomic number) elements …

Chemical mechanisms of nanoparticle radiosensitization and radioprotection: a review of structure-function relationships influencing reactive oxygen species

D Howard, S Sebastian, QVC Le, B Thierry… - International Journal of …, 2020 - mdpi.com
Metal nanoparticles are of increasing interest with respect to radiosensitization. The physical
mechanisms of dose enhancement from X-rays interacting with nanoparticles has been well …

Prospects of nanoparticle-based radioenhancement for radiotherapy

LRH Gerken, ME Gerdes, M Pruschy… - Materials horizons, 2023 - pubs.rsc.org
Radiotherapy is a key pillar of solid cancer treatment. Despite high level of conformal dose
deposition, radiotherapy is limited due to co-irradiation of organs-at risk and subsequent …

Main approaches to enhance radiosensitization in cancer cells by nanoparticles: A systematic review

BB Abdollahi, R Malekzadeh, FP Azar… - Advanced …, 2020 - pmc.ncbi.nlm.nih.gov
In recent years, high atomic number nanoparticles (NPs) have emerged as promising radio-
enhancer agents for cancer radiation therapy due to their unique properties. Multi …

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

M Salah, H Akasaka, Y Shimizu, K Morita… - Journal of Experimental …, 2022 - Springer
Background Despite recent advances in radiotherapy, radioresistance in patients with
pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells …

[HTML][HTML] Nanoparticle-based radiosensitization strategies for improving radiation therapy

H Shen, H Huang, Z Jiang - Frontiers in Pharmacology, 2023 - frontiersin.org
Radiotherapy remains the mainstay treatment for a variety of cancer forms. However, the
therapeutic efficiency of radiation is significantly limited by several aspects, including high …

Harnessing tumor microenvironment for nanoparticle‐mediated radiotherapy

S Zhu, Z Gu, Y Zhao - Advanced Therapeutics, 2018 - Wiley Online Library
Recent years have witnessed the dramatic improvement of nanoparticle‐mediated
radiotherapy in preclinical or even clinical cancer research. Among the extensive …

Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy

M Nakayama, CL Smith, BN Feltis, TJ Piva… - Physica Medica, 2020 - Elsevier
Abstract Purpose Titanium dioxide nanoparticles (TiO 2 NPs) have been investigated for
their role as radiosensitisers for radiation therapy. The study aims to increase the efficiency …