Vasculature organotropism in drug delivery

A Amruta, D Iannotta, SW Cheetham, T Lammers… - Advanced Drug Delivery …, 2023 - Elsevier
Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …

Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications

RP Carney, RR Mizenko, BT Bozkurt, N Lowe… - Nature …, 2024 - nature.com
Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …

[HTML][HTML] Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization

G Su, D Zhang, T Li, T Pei, J Yang, S Tu, S Liu, J Ren… - Bone Research, 2023 - nature.com
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic
calcification and pathological calcified osteoarthritis and in wound repair of the skeletal …

A materials science approach to extracellular matrices

N Bock, M Delbianco, M Eder, R Weinkamer… - Progress in Materials …, 2024 - Elsevier
Extracellular matrices (ECMs) are foundational to all biological systems and naturally
evolved as an intersection between living systems and active materials. Despite extensive …

The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition

S Arif, S Larochelle, B Trudel, C Gounou… - Journal of …, 2024 - Wiley Online Library
Microvesicles (MVs) are a subtype of extracellular vesicles that can transfer biological
information over long distances, affecting normal and pathological processes including skin …

[HTML][HTML] Extracellular vesicles on the move: Traversing the complex matrix of tissues

S Arif, VJ Moulin - European Journal of Cell Biology, 2023 - Elsevier
Extracellular vesicles are small particles involved in intercellular signaling. They are
produced by virtually all cell types, transport biological molecules, and are released into the …

Impacts of tissue context on extracellular vesicles‐mediated cancer–host cell communications

N Nishida‐Aoki, T Ochiya - Cancer Science, 2024 - Wiley Online Library
Tumor tissue is densely packed with cancer cells, non‐cancerous cells, and ECM, forming
functional structures. Cancer cells transfer extracellular vesicles (EVs) to modify surrounding …

[HTML][HTML] Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction

B Martins, M Pires, AF Ambrósio, H Girão… - Journal of Biomedical …, 2024 - Springer
Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular
degeneration (AMD), loom as threats to vision, causing detrimental effects on the structure …

Development of in vitro model of exosome transport in microfluidic gut-brain axis-on-a-chip

GM Seo, H Lee, YJ Kang, D Kim, JH Sung - Lab on a Chip, 2024 - pubs.rsc.org
The gut communicates with the brain in a variety of ways known as the gut–brain axis (GBA),
which is known to affect neurophysiological functions as well as neuronal disorders …

Direct and cell-mediated EV-ECM interplay

O Smirnova, Y Efremov, T Klyucherev, M Peshkova… - Acta Biomaterialia, 2024 - Elsevier
Extracellular vesicles (EV) are a heterogeneous group of lipid particles excreted by cells.
They play an important role in regeneration, development, inflammation, and cancer …