Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Matrix metalloproteinases (MMPs) are an important class of enzymes in the body that
function through the extracellular matrix (ECM). They are involved in diverse …

Anemia is common in colorectal cancer (CRC) but its relationships with tumor
characteristics, systemic inflammation, and survival have not been well characterized. In this …

Background: Higher-grade inflammatory infiltrate is a promising marker for better prognosis
in colorectal cancer (CRC). However, the knowledge on the interrelationships between …

Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting
enzymes as they degrade extracellular matrix components, thus increasing the invasion of …

Neutrophils are the key cells of our innate immune system mediating host defense via a
range of effector functions including phagocytosis, degranulation, and NETosis. For this …

Recent studies have reported of an association between high serum apolipoprotein A1
(APOA1) levels and favorable prognosis in several malignancies, while the significance of …

Abstract ADGRF5 (GPR116) has been identified as a facilitator of breast cancer cell
migration and metastasis, yet the underlying mechanisms remain largely elusive. Our …

Background Cancer cachexia is a complex wasting syndrome affecting patients with
advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein …