Stroke is the most frequent cause of secondary epilepsy in the elderly. The incidence of
cerebral stroke is increasing with the extension of life expectancy, and the prevalence of …

Status epilepticus (SE) is an emergency condition that can cause permanent brain damage
or even death when generalized convulsive seizures last longer than 30 min. Controlling the …

Introduction Alzheimer's disease (AD) is a progressive brain disorder accompanied with
synaptic failures and decline in cognitive and learning processes. Protease-activated …

Epilepsy is a nervous system disease caused by abnormal discharge of brain neurons,
which is characterized by recurrent seizures. The factors that induce epilepsy include …

Recent studies about the novel antidepressant agomelatine, which is a mixed MT 1 and MT
2 melatonin receptor agonist and 5HT 2C serotonin receptor antagonist possessing an …

Coagulation mechanisms are critical for maintaining homeostasis in the central nervous
system (CNS). Thrombin, an important player of the coagulation cascade, activates protease …

The blood-brain barrier (BBB) is a unique structure that controls substances exchange
between the systemic circulation and the brain. Disruption of its integrity contributes to the …

Abstract Protease-activated receptor 1 (PAR1) is an important contributor to the
pathogenesis of a variety of brain disorders associated with a risk of epilepsy development …

Background Brain thrombin activity is increased following acute ischemic stroke and may
play a pathogenic role through the protease-activated receptor 1 (PAR1). In order to better …

Background This study was performed to test the hypothesis that systemic leukocyte gene
expression has prognostic value differentiating low from high seizure frequency refractory …