Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

The homeobox gene PROX1 is critical for organ development during embryogenesis. The
Drosophila homologue, known as prospero has been shown to act as a tumor suppressor by …

Glioblastoma multiforme (GBM) is the most common form of primary brain tumor in adults,
often characterized by poor survival. Glioma-initiating cells (GiCs) are defined by their …

The foundation of the diverse metazoan nervous systems is laid by embryonic patterning
mechanisms, involving the generation and movement of neural progenitors and their …

Master transcription factors have the ability to direct and reverse cellular identities, and
consequently their genes must be subject to particular transcriptional control. However, it is …

Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism
invokes many adverse systemic events including thrombocytopenia, vascular reactions and …

The dentate gyrus of the hippocampus continues generating new neurons throughout life.
These neurons originate from radial astrocytes within the subgranular zone (SGZ). Here, we …

Bone morphogenetic proteins (BMPs) are considered important regulators of neural
development. However, results mainly from a wide set of in vitro gain-of-function …

During embryonic development, cells must divide to produce appropriate numbers, but later
must exit the cell cycle to allow differentiation. How these processes of proliferation and …

Adult hippocampal neurogenesis drastically diminishes with age but the underlying
mechanisms remain unclear. Here, age-related influences on the hippocampal early …