Pediatric low-grade glioma in the era of molecular diagnostics

S Ryall, U Tabori, C Hawkins - Acta neuropathologica communications, 2020 - Springer
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

Challenges in the treatment of glioblastoma: multisystem mechanisms of therapeutic resistance

EK Noch, R Ramakrishna, R Magge - World neurosurgery, 2018 - Elsevier
Glioblastoma is one of the most lethal human cancers, with poor survival despite surgery,
radiation treatment, and chemotherapy. Advances in the treatment of this type of brain tumor …

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

DN Louis, P Wesseling, K Aldape, DJ Brat, D Capper… - 2020 - Wiley Online Library
Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …

Genomes for kids: the scope of pathogenic mutations in pediatric cancer revealed by comprehensive DNA and RNA sequencing

S Newman, J Nakitandwe, CA Kesserwan, EM Azzato… - Cancer discovery, 2021 - AACR
Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-
risk disease. Here, we used a three-platform sequencing approach, including whole …

The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

A Villani, S Davidson, N Kanwar, WW Lo, Y Li… - Nature Cancer, 2023 - nature.com
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …

Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult brain tumor patients

AM Miller, L Szalontay, N Bouvier, K Hill… - Neuro …, 2022 - academic.oup.com
Background Safe sampling of central nervous system tumor tissue for diagnostic purposes
may be difficult if not impossible, especially in pediatric patients, and an unmet need exists …

The genetic landscape of ganglioglioma

M Pekmezci, JE Villanueva-Meyer, B Goode… - Acta neuropathologica …, 2018 - Springer
Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for
approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known …

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective

R Mathur, Q Wang, PG Schupp, A Nikolic, S Hilz… - Cell, 2024 - cell.com
Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral
heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection …

The University of California San Francisco preoperative diffuse glioma MRI dataset

E Calabrese, JE Villanueva-Meyer, JD Rudie… - Radiology: Artificial …, 2022 - pubs.rsna.org
The University of California San Francisco Preoperative Diffuse Glioma MRI Dataset |
Radiology: Artificial Intelligence RSNA "skipMainNavigation" closeDrawerMenuopenDrawerMenu …

Pediatric high-grade glioma: current molecular landscape and therapeutic approaches

S Braunstein, D Raleigh, R Bindra, S Mueller… - Journal of neuro …, 2017 - Springer
High-grade pediatric central nervous system glial tumors are comprised primarily of
anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High …