Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …

Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

Importance It is increasingly evident that Parkinson disease (PD) is not a single entity but
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …

Tremor in Parkinson's disease has several mysterious features. Clinically, tremor is seen in
only three out of four patients with Parkinson's disease, and tremor-dominant patients …

Abstract See Schrag and Politis (doi: 10.1093/aww190) for a scientific commentary on this
article. Apathy, which can occur separately or in combination with depression and anxiety, is …

Parkinson's disease is a chronic neurodegenerative disorder characterized by the motor
symptoms of bradykinesia, tremor, rigidity and postural instability. However, non-motor …

Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Over the past three decades, neuroimaging studies—including structural, functional and
molecular modalities—have provided invaluable insights into the mechanisms underlying …

Background: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has
anxiolytic properties, but no study has been conducted to evaluate the effects of CBD on …