[HTML][HTML] Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Y Jia, L Yu, T Ma, W Xu, H Qian, Y Sun, H Shi - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles, especially small extracellular vesicles (sEVs) are now accepted as
important messengers in cell-to-cell communication and as a promising drug delivery …

[HTML][HTML] An emerging focus on lipids in extracellular vesicles

T Skotland, K Sagini, K Sandvig, A Llorente - Advanced drug delivery …, 2020 - Elsevier
Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated
material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles

JP Bost, H Barriga, MN Holme, A Gallud, M Maugeri… - ACS …, 2021 - ACS Publications
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …

The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery

S Ghadami, K Dellinger - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins,
various functions, and unique lipid and protein compositions have been introduced as …

Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

[HTML][HTML] New advances in exosome-based targeted drug delivery systems

D Ferreira, JN Moreira, LR Rodrigues - Critical Reviews in Oncology …, 2022 - Elsevier
In recent years, various drug nano-delivery platforms have emerged to enhance drug
effectiveness in cancer treatment. However, their successful translation to clinics have been …

Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution

AM Silva, E Lázaro‐Ibáñez… - Journal of …, 2021 - Wiley Online Library
Abstract Extracellular Vesicles (EVs) have been intensively explored for therapeutic delivery
of proteins. However, methods to quantify cargo proteins loaded into engineered EVs are …

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology

AG Yates, RC Pink, U Erdbrügger… - Journal of …, 2022 - Wiley Online Library
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

Extracellular vesicles as delivery systems at nano-/micro-scale

P Fu, J Zhang, H Li, M Mak, W Xu, Z Tao - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in
drug delivery and bioimaging. With more characteristics of EVs explored through …