Advanced glycation end-products are a complex and heterogeneous group of compounds
that have been implicated in diabetes related complications. At present it is not known if they …

Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost
25%. This increase may be partially attributable to lifestyle changes and increased global …

Recent studies suggested that interruption of the interaction of advanced glycation end
products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Advanced glycation end products (AGE) contribute to diabetic tissue injury by two major
mechanisms, ie, the alteration of extracellular matrix architecture through nonenzymatic …

Chronic kidney disease is an emerging health problem worldwide. The eye shares striking
structural, developmental, and genetic pathways with the kidney, suggesting that kidney …

OBJECTIVE—To examine prospectively the relationship between diabetes, glycemic
control, and spirometric measures. RESEARCH DESIGN AND METHODS—From a …

Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with
decline in renal function. The underlying pathogenic link between chronic hyperglycemia …

Diabetic nephropathy is a major cause of morbidity and mortality in diabetic patients. Two
key mechanisms implicated in the development of diabetic nephropathy include advanced …

Advanced glycation end products (AGEs) are a heterogeneous group of protein and lipids to
which sugar residues are covalently bound. AGE formation is increased in situations with …