The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

Growing evidence suggests that cytoplasmic actin filaments are essential factors in the
modulation of nuclear shape and function. However, the mechanistic understanding of the …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

Maintaining physical connections between the nucleus and the cytoskeleton is important for
many cellular processes that require coordinated movement and positioning of the nucleus …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

During cell migration, the movement of the nucleus must be coordinated with the
cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …