Joint distribution of protein concentration and cell volume coupled by feedback in dilution
We consider a protein that negatively regulates the rate with which a cell grows. Since less
growth means less protein dilution, this mechanism forms a positive feedback loop on the …
growth means less protein dilution, this mechanism forms a positive feedback loop on the …
Amplification of noisy gene expression by protein burden: An analytical approach
The overexpression of many proteins can often have a detrimental impact on cellular growth.
This expression-growth coupling leads to positive feedback-any increase of intracellular …
This expression-growth coupling leads to positive feedback-any increase of intracellular …
Heavy-tailed distributions in a stochastic gene autoregulation model
P Bokes - Journal of Statistical Mechanics: Theory and …, 2021 - iopscience.iop.org
Synthesis of gene products in bursts of multiple molecular copies is an important source of
gene expression variability. This paper studies large deviations in a Markovian drift-jump …
gene expression variability. This paper studies large deviations in a Markovian drift-jump …
A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks
In this paper, a finite volume discretization scheme for partial integro-differential equations
(PIDEs) describing the temporal evolution of protein distribution in gene regulatory networks …
(PIDEs) describing the temporal evolution of protein distribution in gene regulatory networks …
Stochastic gene expression in proliferating cells: Differing noise intensity in single-cell and population perspectives
Random fluctuations (noise) in gene expression can be studied from two complementary
perspectives: following expression in a single cell over time or comparing expression …
perspectives: following expression in a single cell over time or comparing expression …
Quantifying noise modulation from coupling of stochastic expression to cellular growth: An analytical approach
The overexpression of many proteins can often have a detrimental impact on cellular growth.
This expression-growth coupling leads to positive feedback-any increase of intracellular …
This expression-growth coupling leads to positive feedback-any increase of intracellular …
Comparative analysis of noise-attenuation mechanisms in gene expression: From single cells to cell populations
Negative feedback regulation is a well-known motif for suppressing deleterious fluctuations
in gene product levels. We systematically compare two scenarios where negative feedback …
in gene product levels. We systematically compare two scenarios where negative feedback …
Optimisation of gene expression noise for cellular persistence against lethal events
Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …
Comparing negative feedback mechanisms in gene expression: From single cells to cell populations
Negative feedback regulation is a well-known motif for suppressing deleterious fluctuations
in gene product levels. We systematically compare two scenarios where negative feedback …
in gene product levels. We systematically compare two scenarios where negative feedback …
Stationary distributions and metastable behaviour for self-regulating proteins with general lifetime distributions
Regulatory molecules such as transcription factors are often present at relatively small copy
numbers in living cells. The copy number of a particular molecule fluctuates in time due to …
numbers in living cells. The copy number of a particular molecule fluctuates in time due to …