Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
Fragile sites in cancer: more than meets the eye
TW Glover, TE Wilson, MF Arlt - Nature Reviews Cancer, 2017 - nature.com
Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …
Cancer aneuploidies are shaped primarily by effects on tumour fitness
J Shih, S Sarmashghi, N Zhakula-Kostadinova… - Nature, 2023 - nature.com
Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …
Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)
Single-cell genomics is important for biology and medicine. However, current whole-
genome amplification (WGA) methods are limited by low accuracy of copy-number variation …
genome amplification (WGA) methods are limited by low accuracy of copy-number variation …
The human pre-replication complex is an open complex
J Li, J Dong, W Wang, D Yu, X Fan, YC Hui, CSK Lee… - Cell, 2023 - cell.com
In eukaryotes, DNA replication initiation requires assembly and activation of the
minichromosome maintenance (MCM) 2–7 double hexamer (DH) to melt origin DNA …
minichromosome maintenance (MCM) 2–7 double hexamer (DH) to melt origin DNA …
DNA replication stress and chromosomal instability: dangerous liaisons
T Wilhelm, M Said, V Naim - Genes, 2020 - mdpi.com
Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …
[HTML][HTML] Completing genome replication outside of S phase
R Bhowmick, ID Hickson, Y Liu - Molecular Cell, 2023 - cell.com
Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …
MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7
onto replication origins in G1-phase forms the basis of replication fork establishment in S …
onto replication origins in G1-phase forms the basis of replication fork establishment in S …
Cohesin maintains replication timing to suppress DNA damage on cancer genes
Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism
underlying its role in tumorigenesis is unclear. Here, we found that depletion of RAD21, a …
underlying its role in tumorigenesis is unclear. Here, we found that depletion of RAD21, a …
[HTML][HTML] Accurate identification of DNA replication origin by fusing epigenomics and chromatin interaction information
DNA replication initiation is a complex process involving various genetic and epigenomic
signatures. The correct identification of replication origins (ORIs) could provide important …
signatures. The correct identification of replication origins (ORIs) could provide important …